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(ii) Estimate d N / d S = 0.045 between the human and mouse genes by the likelihood method using PAML.
To address this problem, we have also analyzed aligned amino acid sequences of the 23 species by the likelihood method.
PAML also implemented a Suzuki and Gojobori-style [ 24] method to test the effects of selection at individual sites with changes according to ancestral states reconstructed by the likelihood method.
As gene flow cannot be ruled out in our study system, effective population size estimates were firstly obtained by the likelihood method of and Wang and Whitlock (2003) implemented in the program MNE2 as it provides estimates of the effective population size and immigration rate jointly.
For a coding sequence with Lc codon locations, the model has six mutation parameters (τ, κ, c, and 3 π j * ) and (20 − 1) Lc values of F I, K. Information from all codon locations is used by the likelihood method to estimate the value of the six mutation parameters.
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The positioning algorithms that exploit the soft information obtained by the linearization and the likelihood method perform equally well.
Risk estimates were computed by the maximum likelihood method; the confidence intervals (CIs) of the RRs were determined from the likelihood profiles (LPs).
A phylogenetic tree was constructed by the Maximum Likelihood method, and the robustness of the phylogenetic analysis was determined by bootstrap analysis with 500 replications.
Estimating the parameters by the maximum likelihood method requires numerical optimization of the likelihood.
The fraction of chlamydia infected women who progress to PID is obtained for each hypothetical process by the maximum likelihood method using the results of the RCT.
This paper compares the variance of random errors estimated by the maximum likelihood method with the assumed ones.
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