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The more modest differences between adult and neonatal effector cells were masked by the large expression differences in naive cells.
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Results in these studies demonstrate that exposure to 150uM CoCl2 cause a hypoxic response in +SA mammary tumor cells grown in culture, as evidenced by the large increased expression of the hypoxia-inducible factor, HIF-1 α, without causing significant adverse effects on +SA cell viability or growth.
These observations suggest that they are not independent expression modules, but might be subsets of the same large expression module regulated by multiple interacting motifs.
These discrepancies can be rationalized by the large uncertainty of low expression genes which accumulate in the underexpression spot.
In the current study, this biological variation was deliberately included and was mainly reflected by the large differences in gene expression profiles of the control populations tested.
Besides up-regulation during lactation, a chief role of PPARG in mammary lipid metabolism is supported by the large up-regulation in expression of PPARGC1A and LPIN1 two important PPARγ co-factors.
We believe the under-performance of the K2P invariants may be attributed to additional noise in the data created by the large number of invariant expressions.
We suspected that this result might be explained by the large heterogeneity in the Nox2 expression level of PLB-985 clones (Fig. 6b).
We constructed a large expression set by merging seven of the largest breast cancer data sets together [ 2, 24, 40- 44].
This may be explained by the large biological errors of the gene expression levels of both AP2 and AGL15, which were comparable to the measurements.
Additionally, genes specifically associated with each condition were identified, as exemplified by the large number of genes (441) whose expression was specifically modulated during growth in sophorose compared to glucose.
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