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A framework to automatize handling of the various free parameters required by the key node analysis algorithm and to estimate false discovery rate using random shuffling of the input nodes shall be described elsewhere (manuscript in preparation).
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The primary collective functions of each PPI subnetwork could be stamped by the key nodes of proteins or a group of proteins with the similar functions in the specific physiological processes in PPI subnetwork.
As described earlier [41], we empowered the key node analysis by the so-called "pathway persistence".
These methods are using the node-deletion method by removing the key nodes during evaluation and observing the changes (such as network disconnection) of energy consumption in network after the key node is removed or failed.
This was done using the key node functionality of ExPlain.
Which region acts as the key node?
The key nodes by voltage amplitudes are sorted and node 4 has the lowest value.
The key nodes by voltage amplitudes are searched and node 6 has the lowest value.
How do we find the key nodes regulated by these molecular signaling systems to exploit as therapies?
They can wreck the key nodes of complex international systems.
The games will also be running throught the key nodes of the Limelight network.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com