Therefore, we first investigated, by RNA interference experiments, the putative involvement of these RING finger E3 ligases in controlling the disposal of V247M α-sarcoglycan mutant.
Thus, we first investigated its possible involvement in the ubiquitination of sarcoglycans by RNA interference experiments.
The results were further demonstrated by RNA interference experiments in vitro.
14, 21– 24 Whilst the precise role of the trypanosome orthologue GSK3 short kinase (TbGSK3) in the bloodstream form of T. brucei has yet to be determined in terms of parasite biology, the importance of this enzyme has been demonstrated by RNA interference experiments that showed decreased growth rates for parasites in in vitro culture.
Response of E2F target genes were validated by real-time PCR, and the posited role of E2F2 in breast cancer cell proliferation was tested by RNA interference experiments.
By using RNA interference experiments, we show that the stability of growing procentrioles is regulated by the microtubule-stabilizing protein CAP350, independently of hSAS-6 and CPAP which initiate procentriole growth.
It is possible that more existing drugs that act against the targets identified by our RNA interference experiments may be senolytic.
These features prompted us to investigate the role of this complex during centriole duplication initiation and elongation in RPE-1 cells by RNA interference experiments and nocodazole treatment.
Joanna Cox and Shuhong Luo demonstrated that a Ca2+-ATPase is localized to acidocalcisomes and the plasma membrane of Trypanosoma brucei, the etiologic agent of African sleeping sickness, and is essential for cell growth, as demonstrated by RNA interference experiments.
Silencing of Twist1 by RNA interference experiments in cell lines decreased cell number and viability in response to Imatinib, whereas overexpression of Twist1 led to improved Imatinib resistance of previously sensitive cell lines.
