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However, once even a few cells manage to establish conditions for growth at distant sites, development of tumors at those sites seeded by the initial cells may become very efficient, resulting in poor prognosis for the patients (Gerges et al. 2010).
This pattern was caused by the initial cells growing into microcolonies which, after running into each other, were forced to grow upward (Momeni et al., 2013).
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The size can be controlled by the initial cell density per well and within this spheroids, bone formation has been induced.
The definition of cell fold-increase is defined and calculated based on the final total cell number divided by the initial cell number.
However, when all the cell proliferation was inhibited, the wound healing process was completely deterred except for the small area near the wound edge which was covered by the initial cell migration of superbasal cells (data not shown).
While the neural commitment was density independent, the maturation efficiency was dictated by the initial cell plating density thus questioning how appropriate could it be to regard neurogenesis that would include both commitment and maturation; as a default transition in the absence of inhibitory signals [13], [46]?
In all these cases, the empty spot created by the initial cell death is filled.
The rate and quality of new tissue formation are greatly affected by the initial cell adhesion to the scaffolds.
The propensity p0are derived from the corresponding reaction rate, k, by dividing the latter by the initial cell volume, p0= k/ V0.
The resulting data were normalized to the signal generated by the initial cell inoculum, which was measured immediately after cardiac injection.
The difficulty in detecting rare infected cells immediately after mucosal HIV transmission has hindered our understanding of the initial cells targeted by the virus.
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