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In a hypothetical feedback loop, endogenous TLR ligands generated by the inflammatory processes may result in chronic stimulation of synovial cells [112].
Cytokines released by the inflammatory processes predispose to anorexia and lethargic behaviour (Johnson, 1997).
Generalized bone loss in postmenopausal women with RA will occur as a result of decreased estrogen levels accelerating bone turnover and systemic bone loss and by the inflammatory processes resulting in systemic increase of several cytokines shown to up regulate systemic bone turnover.
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CAL is mediated by enhanced matrix metalloproteinase activity and elastin breakdown induced by the inflammatory process in the coronary artery wall.
In the most severe cases in who TMJ is too severely damaged by the inflammatory process to be cured in a conservative way, implants are used to replace the TMJ.
A typical morphological finding in AIPC was the involvement of the intrapancreatic bile duct, which was severely affected by the inflammatory process with stenosis of the lumen in 16 cases (48%).
Some authors [ 5] consider that anemia is also caused by the inflammatory process.
In addition, the bone tissue formation in this region may be inhibited by the inflammatory process associated with the foreign body biological response on the remained metallic particles.
In animal models of inflammatory arthritis, erosion of subchondral bone contributes significantly to cartilage loss, as the scaffolding bone is destroyed by the inflammatory process.
We suggest that tissue damage is initiated by oxidative burst in activated microglia and macrophages, which is most likely induced by the inflammatory process.
It is conceivable that these proteins were released into the CSF as a result of membrane rupture and cell death triggered by the inflammatory process.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com