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Is this computer number more accurate than any number(s) generated by the imputation methods?
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To maximise the number of twin pairs available for genetic analysis, missing item responses were imputed where possible by using the imputation methods in PRELIS 2.30 (Jöreskog and Sörbom 1999).
Overall, GS accuracies were least affected by the imputation method for dataset version NA20, and most affected by the imputation method for dataset version NA70.
17 A sensitivity analysis was performed to examine whether the associations were influenced by the imputation method for missing BMI.
Applying significance thresholds calculated in this manner produced essentially the same results as those obtained by the imputation method.
However, the complete case analysis suggests that the findings were not driven by the imputation method used.
In general, predictive models resulting from the combined methods were more similar to those generated by the imputation method than to those according to the bootstrap method.
The latter method can be implemented if marginal maximum likelihood or some Bayesian estimation methods are applied to avoid any bias caused by the imputation method.
Demographic and socioeconomic variables were inherently controlled for the health outcomes prevalence by the imputation method, but residual confounding and confounding by unmeasured characteristics is possible.
This step was repeated four more times, to create five datasets with completed outcome validated status, either as determined by chart review or as assigned by the imputation method.
Note: a general procedure/command stated by the authors, and the imputation methods that were inferred by the reviewers are not included in this category.
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