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Results from DYHM using a depth-3 hierarchy (8 groups) at various values of
Significant GO term enrichment was determined by the hypergeometric method with Hochberg FDR multiple-test correction [ 55], with the FDR set to 0.05.
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Moreover, the hypergeometric method allowed for a better performance by thresholding genes with low scores.
These pathways, which are the top-ranked pathways by the weighted hypergeometric method, are more biologically relevant than the top-ranked pathways generated by the standard hypergeometric method.
The top-10 most significant pathways detected by hypergeometric enrichment are shown in Table 2. Table 3 shows the top-10 pathways enriched by the weighted hypergeometric method.
Table 3 lists the first 10 genes--along with their first 10 supporting publications--returned by GLAD4U Hypergeometric method that were not in the corresponding gold standards for the terms "apoptosis" and "hypertension" (see additional files 1 and 2 for the complete lists of genes and supporting publications).
Representation factor and P-values calculated by the hypergeometric distribution (see Methods) were used to evaluate the overlaps.
We also compared our method with the hypergeometric distribution method.
The alignments A1-A2 and A1-B1 are examined base-by-base using the hypergeometric random walk method of [ 18], which utilizes a cumulative score representing the difference in distances between these sequence pairs.
We selected those pathways having adjusted P-values of less than 0.01 calculated by the hypergeometric test followed by the Benjamini-Hochberg method [ 31], which was implemented in WebGestalt.
Statistical enrichment of a category was quantified using the Hypergeometric test method.
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CEO of Professional Science Editing for Scientists @ prosciediting.com