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To avoid potential confounding of coexpressed genes, duplicated genes were removed by a novel algorithm that clusters genes together according to their annotations and genomic locations as determined by the hypergeometric distribution (MW and KP, manuscript in preparation).
The probability that the intersection of these two groups would include 23 probes given a total of 12,626 probes on the HG-U95Av2 array was computed by the hypergeometric distribution using the R statistical programming language (http://www.R-project.org) and the p-value (p = 0.005) was computed.
A schematic representation of the procedure used to validate links is provided in Fig. 4. The null hypothesis of random co-coccurecence is again described by the hypergeometric distribution, which naturally takes into account the heterogeneity of the system due to the different size of the cast of movies.
Given two strains a and b and two segments i and j, the probability to obtain hamming distances equal to diab and djab by random chance only is given by the hypergeometric distribution
This probability is given by the hypergeometric distribution function.
* P-value was calculated by the hypergeometric distribution.
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In the pathway analysis, the P values were calculated by Gene Set Enrichment Analysis (GSEA) algorithm by estimating the hypergeometric distribution of overlapping genes over all genes in the gene universe.
We used our algorithm to investigate whether the null hypothesis used by the standard method was appropriate by comparing the hypergeometric distribution with an empirical distribution for the number of predicted target genes belonging to a GO term for randomly sampled miRNAs.
The statistical significance of functional GO Slim enrichment was evaluated by using the hypergeometric distribution, whereas multiple hypotheses testing was done by using FDR [ 80].
First, we investigated the enrichment of the 61 differentially expressed proteins across two different ontological categories using GeneGo canonical pathway maps and GeneGo processes by calculating the hypergeometric distribution p-value of this list with respect to each category.
The enriched GO term was tested by using the hypergeometric distribution.
More suggestions(15)
by the hypergeometric model
by the hypergeometric method
by the hypergeometric probability
by the hypergeometric function
by the hypergeometric polygenic
by the initial distribution
by the unequal distribution
by the skewed distribution
by the geographic distribution
by the widespread distribution
by the spatial distribution
by the actual distribution
by the hypergeometric test
by the normal distribution
by the statistical distribution
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