Cell death induced by Chk1 inhibition was accompanied by the hallmarks of apoptosis such as nuclear DNA condensation (Fig. 2B), mitochondrial cytochrome c release, caspase-3 activation (Fig. 5D,E), and phosphatidylserine exposure (Fig. 5F).
For this reason, the understanding of gene expression profiles, which provide signatures of all the active genes and their interconnections in a cell, contain valuable information about the functioning of key pathways, as expressed by the hallmarks of cancer and, hence, enable a practical investigation of functional mechanisms thereof [ 28- 36].
The Paris designer Dominique Kieffer, whose chic linens are favorites with French interior designers, says her latest line was inspired by the hallmark colors (pale pinks and greens) of the 18th-century Scottish architect and designer Robert Adam.
(About that title: Ms. Macomber is a best-selling author who earned a lifetime achievement award from the Romance Writers of America; four of her novels have been adapted into television movies, including three by the Hallmark Channel).
MC's language profile was characterised by the hallmark propositional language impairment despite well-preserved naming, reading, repetition and comprehension skills.
This intriguing result may be explained by the hallmark characteristic of anti-idiotypic antibodies that they recognize each other, thereby masking anti-cPR3 reactivity, but we were not able to prove this.
On the genetic level, MCL is characterized by the hallmark translocation t(11 14) that is present in most cases with few exceptions.
Alzheimer's disease (AD) is characterized by the hallmark pathology, comprised of widespread amyloid-beta (Aβ) deposition, neurofibrillary tangle formation, and extensive neurodegeneration in the brain.
The WRKY family contains one or two highly conserved WRKY domains characterized by the hallmark heptapeptide WRKYGOK and a zinc-finger structure distinct from other known zinc-finger motifs.
Alzheimer's disease (AD) is the most common cause of dementia worldwide affecting the elderly population, characterized by the hallmark pathology of amyloid- β (A β) deposition, neurofibrillary tangle (NFT) formation, and extensive neurodegeneration in the brain.
AD is the most common cause of dementia worldwide, affecting the elderly population, characterized by the hallmark pathology of amyloid-β (Aβ) deposition, neurofibrillary tangle (NFT) formation, and extensive neuronal degeneration in the brain.
