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Finally, I studied whether gene expression divergence was affected by the gene function of paralogs.
The frequency of these non-synonymous mutations are relatively small, caused by the gene function or gene activity.
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Gene expression levels are not universally affected by histone methylation levels, and the relationships between the two differ by the gene functions.
The protein encoded by the gene functions in neural development, so mice lacking it have abnormal spinal cords and sensory ability, including pain sensitivity.
These data show that APR6 knockout tended to uptake VirE2 more easily at the later stage of the AMT process, suggesting that virulence proteins import could be inhibited by the gene functions of ARP6.
This should induce the immediate vector elimination upon repair of the gene function by two events of homologous recombination of the genomic duplication as described previously [29].
Transgenic zebrafish have been routinely produced to understand the gene function by injecting the transgene into the eggs and following its expression in cell lineages [ 8].
First, the gene functions given by GO were analyzed.
By looking at the genes' function in the body, it allows researchers to figure out the processes going wrong in Alzheimer's disease.
The CNVs with pattern discordance may make an impact on these diseases by interfering the genes' functions explicitly or through cell-recognition in complicated immune pathway.
The protein encoded by the NRAS gene functions in the same pathway as KRAS and mutations in this gene have been found in 3% of CRC (http://www.sanger.ac.uk/genetics/CGP/cosmic/). The NRAS gene is highly expressed in CRC (http://www.oncomine.org), hence it is to be expected that tumors with an NRAS mutations are resistant to EGFR targeted therapy.
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