We propose to redress the deficiency by formulating the functional study of biological networks as a control problem of dynamical systems.
As suggested by the functional studies presented in this report, CupB2 is likely the chaperone of CupB1, but not CupB6 or CupB5.
Therefore, the sequence variation should be partly responsible for their functional diversification, as indicated by the functional studies of OsNIP2 1 and OsNIP2 2 [ 10, 11, 13].
Hence, we believe that the evolutionary scenario presented by the MUSCLE-RAxML tree is not a likely occurrence, and is not well supported by the functional studies of RADα and RADβ.
Segmented mineralisation of the notochord determines the localization of vertebral bodies, and notochord mineralisation is thereby crucial for normal formation of the vertebrae, as the functional study by Willems et al. [ 8] has demonstrated.
This interpretation of the immunohistochemistry data is strengthened by the results of the functional studies which suggest involvement of both COX isoenzymes in signalling from MD to JGA to stimulate renin secretion.
It may become more apparent when more insight into function of the intron 5 is available by the future functional studies.
The results of the present study indicate that exposure to LED light in this albino rat model can induce retinal damage as evidenced by the functional ERG study, IHC, TUNEL, and TEM examinations.
To definitively demonstrate the association between rare variants and a disease can be difficult, often requiring clustering of multiple rare variants in one gene (Bodmer and Bonilla., 2008), or by conducting a functional study on the rare variant and the gene.
ACS was diagnosed by positive functional study, cardiac catheterization, or cardiac event during 30-day follow-up.
