Sentence examples for by the functional importance from inspiring English sources

We aligned 39 vertebrate PGRP sequences for each locus and deduced the ancestral amino acids [ 27] at all internal nodes of the phylogenetic tree, in order to estimate the presence of parallel and convergent substitutions, which may have been driven by the functional importance of sites.

We approach this first by emphasizing the functional importance of genetic variation in agricultural commodities using examples of the corn leaf blight of 1970 in which mitochondrial genetic uniformity contributed to crop failure and subsequent economic losses.

Genome-wide surveys of patterns of gene expression, for example, can help by revealing the functional importance of correlations between gene expression and the development of a phenotype [ 5].

The phosphorylation of PKC by rVvpE was blocked by NAC, indicating that the functional importance of ROS in this regulation.

In order to investigate if this effect was caused by toxicity of this peptide, we knocked-down the ghsr expression by RNAi to confirm the functional importance of the GHS-R in apoptosis in CMT-W1M cell line.

The similarity of our model to the SatP fold is not only supported by mutagenesis data but also suggests the functional importance of multimeric assembly not revealed by co-evolution or conservation analysis alone.

Interestingly, the fully closed mutant Merlin (A585W-Merlin) can no longer be activated by AMOT-CC, pointing to the functional importance of the semi-open conformation of Merlin.

Loss of function mutations in the bHLH domain in one allele of the TWIST1 gene cause Saethre-Chotzen Syndrome (SCS) in humans, an autosomal dominant craniofacial disease caused by gene haploinsufficiency [ 18- 20], denoting the functional importance of the TWIST1 bHLH domain.

Conservation between the human and Dicyema sequences was more strongly observed in the DNA-contacting aa residues (36/37) than in non-contacting residues (64/92) (P < 0.001 by Fisher's exact test), suggesting the functional importance of the former type of residues.

In this paper we advance the measure of the functional importance of ESPs provided by natural areas and permanent cultivations based on their effectiveness at performing the services.

Corresponding mutations in Saccharomyces cerevisiae result in increased sensitivity to replication stress, demonstrating the functional importance of DNA binding by this region of Mcm10 to replication.