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For a full interpretation of the data generated by the functional analysis in IPA we used the "effect on function" feature in IPA, which allowed determining among those significantly-enriched functions, which specific sub-function/s, tissue, or cellular component/s affected the function and in which direction (i.e., increase/decrease the function).
40635_2014_20_MOESM1_ESM.pdf Additional file 1: Table S1.: Modulation over the first 48 h of septic shock for selected genes highlighted by the functional analysis.
The differences in the gene expression across different cancer types may indicate either a general or specific relevance of the gene to the corresponding cancers, which has been partially confirmed by the functional analysis and an extensive literature search.
The above genes may be combined with the candidates predicted by the functional analysis and listed in Table 5.
This hypothesis is strongly supported by the functional analysis of the replicons in vitro, which revealed a major compensatory effect of the second T1087A mutation.
The second GO term obtained by the functional analysis of age- and CR-regulated circulating miRNAs is 'negative regulation of apoptosis'.
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Those genes were found by using the functional analysis from DAVID 6.7 bioinformatic resources [ 61] and GoToolbox [ 62].
The cancer-associated variants were predicted by using the Functional Analysis through Hidden Markov Models (Fathmm) which combine sequence conservation within hidden Markov models (HMMs) [ 54].
Tumor sizes were measured with electronic calipers on high-resolution T1 weighted post contrast images (measured on the 90-120 subtractionractimagemage), following the WHO methodology, the same day of the exam by the same radiologist as required by the clinical protocol [ 31], the functional analysis was performed retrospectively by the same radiologists.
The functional analysis by EMSA and luciferase assay further shows that IRF-5P68 completely loses its DNA-binding and transactivating activities.
The functional analysis by the authors focuses on the second type and seems to ignore the first type.
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