Sentence examples for by the forced expression from inspiring English sources

Direct reprogramming technology can convert various differentiated cell types to other fates by the forced expression of lineage-specific transcription factors.

Induced pluripotent stem (iPS) cells are generated from mouse and human somatic cells by the forced expression of defined transcription factors.

These results showed that Pyk2 regulated the expression of mesenchymal genes and promoted the migratory characteristics of HCC cells which can be attenuated by the forced expression of PRNK to suppress Pyk2 activation.

Numerous laboratories have demonstrated that human and mouse somatic cells can be reprogrammed into pluripotent stem cells or iPS cells by the forced expression of a characterized set of transcription factors (Oct4, Sox2, c-Myc, Klf4, Nanog, and Lin28) in various combinations [1] [10].

Morpholino-induced Nrp1 knockdown in zebrafish impairs intersomitic vessel (ISV) growth, which is rescued by the forced expression of full-length, but not SEA-deficient NRP1 (Wang et al., 2006).

Induced pluripotent stem (iPS) cells are ES cell-like pluripotent cells, generated by the forced expression of defined factors in somatic cells, including Pou5f1/Oct4, Sox2, Klf4 and Myc (4).

Indeed, in embryos in which JAG2 was depleted by shRNA, the forced expression of Hes5 significantly reduced the premature migration of OLPs (Olig2+ from 19.14±1.99 to 3.62±0.53 cells/section; Sox9+ from 28.57±5.73 to 7.09±1.28 cells/section, Figures 7g k).

To test whether Pou3f1 relieves the neural inhibition mediated by the BMP signaling pathway in vivo, we co-electroporated Xenopus BMP4 (xBMP4) with a control vector or with Pou3f1 into the pre-neural plate region of chick embryos at HH stage 3. cSox2 expression was completely repressed by xBMP4 (16/19), whereas the forced expression of Pou3f1 partially recovered cSox2 expression (10/19).

Pluripotent stem cells can be derived by reprogramming somatic cells through the forced expression of pluripotent factors.

In another study by Li et al. [ 16], the forced expression of AMPK-β1 inhibits the growth of H1299 and U2OS cells.

The forced expression of AR by pIRESneo-AR caused an approximately 5 6-fold increase in the expression of AR, but this was not the case with the control vector for AR, pIRESneo.