We designate the fixed parameters by φ, which can be single-point values or fixed distributions representing pharmacokinetic, shower model, and other exposure parameters such as drinking water intake and shower duration.
It is important to note that we do not explicitly model in Eq. 1 the dynamics of viral replication after the dose reduction, but rather replace the fixed parameters by time dependent parameters in the original analytical solution obtained with fixed parameters.
In this model, the distribution of λ k is parameterized by fixed parameters a and b, and the fixed parameter β decides the distance measure between the observed interactions V and the expected interactions V ^.
For the remaining fixed parameters, the values determined by Holgado et al. [32] are used.
First, the fitness of the various genotypes is not a priori given by some fixed parameters or functional relationships, but instead derived from population dynamical considerations.
Moreover, due to the unpredictably varying type of the real emissions, it is impossible to simulate them by EMFs of fixed parameters.
In this work, we present these analytical models, and then show how uncertainty in the input variables and parameters affects the response of the process by comparing the response curve with fixed parameters to the ones with uncertainty.
In the following, we will first establish that such a constant threshold cannot be obtained by a model with fixed parameters and then study the possible scenarios where different subsets of parameters are allowed to vary.
The number of these additional refinement levels is controlled by a fixed parameter or are skipped when all bit-planes happen to decode properly.
Post hoc Bayesian forecasting (i.e., MAXEVAL = 0) was used to predict the plasma concentrations for the validation subjects, by fixing parameters in the structural and variance model to the final estimates, incorporating individual dosing history and covariates, and assuming a typical AAG level of 19.32 μM (median value from all HV in the model building dataset).
