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This is consistent with a switch from oxidative phosphorylation to substrate-level phosphorylation indicated by the expression change of two genes known to be expressed in microorganisms under anaerobic conditions: pyruvate-formate lyase (pfyD) and pyruvate-ferrodoxin oxidorectase (porA) [ 30].
Feedback is an action triggered by the expression change to restore the balance.
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To identify which spacing parameters define the optimal predictor, we varied both spacings simultaneously, and quantified their predictability by averaging the expression change of their 30 highest ranking genes.
The method is based on the idea that regulatory activity changes of miRNAs could be reflected by the expression changes of their target transcripts measured by microarray.
Days 7 and 9 were marked by the expression changes of C/EBPs.
This is further supported by the expression changes of HLA molecules.
The underlying assumption is that regulatory activity by miRNAs could be reflected by the expression changes of their target transcripts.
This hypothesis is supported by the expression changes of the genes involved in ROS generation and scavenging in the SlHUB1- or SlHUB2-silenced plants.
The power of causal analysis is exemplified by the expression changes related to two cell cycle marker genes, PCNA and MKI67.
Previous similar analyses have used a score of more than 10 as a cutoff for identifying relevant gene networks [ 16] with higher values corresponding to networks more likely to be affected by the expression changes seen in the experiment.
Since an organism's response to environmental cues are not guided by the expression changes of just one gene but rather a network of interacting genes, finding differentially expressed transcripts may not tell us much about how these transcripts work together to influence the expression of a trait.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com