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The fundamental role of UHRF in the maintenance of DNA methylation is demonstrated by the dramatic reduction in global CpG methylation in homozygous Uhrf-null ES cells and embryos.
During proliferation of HUVEC, calcium mobilization in response to OT treatment seems to be instrumental in the activation of the NO pathway, as shown by the dramatic reduction of OT-induced NO release when calcium is chelated [28].
This finding is strengthened by the dramatic reduction in the percentage of REM sleep observed in the first day after MPTP, which is highly correlated to the number of dopaminergic TH-ir neurons lost within the SNpc.
Consistent with the Sn- HIV-1NL4-3 binding assay, pre-treatment of TSn with mAb 7D2 reduced infection in the reporter cells as illustrated by the dramatic reduction in luciferase activity (Fig. 5A).
A relative increase in C G mutations, primarily in transitions, has been described in MMR deficient mice [11] [13], [16], [24], [31], [32], [40], [41], but it is not clear if this can be explained solely by the dramatic reduction of mutations at A T sites or if there is also an absolute increase in the frequency of C G mutations.
In the presence of AH23848, mammospheres were actually increased in number, but individual spheres were much smaller as indicated by the dramatic reduction in cells/sphere.
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