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Additional support for this hypothesis was given by the dramatic decrease in developing oocyte numbers upon successful catalase gene depletion by RNAi in female sand flies (fig. 5A and b).
Genetic impairment of autophagy was also performed using shRNA targeting of Atg7, and starved HCT116-BaxKO shAtg7 cells were found to undergo massive osmotic cell death (∼80%) due to defective entry into the autophagic stasis state (<5%) (Fig. 1A), as confirmed by the dramatic decrease in Atg5-Atg12 conjugate in these cells (Fig. 1B).
The severe and peculiar immunological conditions of our 'treatment-naive' patient, reflected by the dramatic decrease of the CD4 cell count (24/μL), might therefore have played a role in the renal disease.
Subsequent treatment with 46 (30 mg kg 1) resulted in a rapid reversal of neuromuscular block as evidenced by the dramatic decrease in time required for spontaneous breathing and a return to a train-of-four (TOF) ratio of 0.9.
This is inferred by the dramatic decrease of prolactin concentration in plasma during the first three days of lactation (Fig. 2) combined with the lack of any change in expression of PRLR, JAK2, and STAT5B during lactation.
Consistent with these results, GlaB strikingly reduced Hh pathway activity as evaluated by the dramatic decrease of the pathway readout Gli1, Gli2 and Ptch1 mRNAs, stemness markers (Nanog, Oct4) as well as growth (cyclins D1 and D2, PCNA) and oncogenic (NMyc) related signals (Fig 5D).
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Candidate molecules and pathways involved in transducing NMDAR activation to KCC2 downregulation include PKC, required for the EGABA depolarization induced by 5 minutes of postsynaptic spiking alone [33], and the BDNF-TrkB pathway, implicated by studies of the dramatic decrease in KCC2 expression following the kindling of seizures in vivo [34] [35].
By contrast, oxidizing the pristine CDC by HNO3 at 80°C results in the dramatic decrease of the specific surface area and micropore volume.
The dramatic decrease of MCAs by the resin-containing diet resulted in CA being the only predominant primary BA, whereas the CA-derived DCA was the major secondary BA in livers of resin-fed mice.
The dramatic decrease of cEPCs accompanied by anti-VEGF treatment may impair endothelial repair capacity and bring unfavorable effects in sepsis.
Pulitzer Prize-winning author Sonia Nazario visited the neighborhood this summer and wrote in the New York Times about the dramatic decrease in violence, noting that programs funded by the U.S. are partially responsible.
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by the dramatic decline
by the considerable decrease
by the dramatic contrast
by the dramatic growth
by the dramatic departure
by the abrupt decrease
by the dramatic coastline
by the dramatic expansion
by the dramatic handling
by the dramatic raid
by the dramatic drop
by the dramatic rise
by the dramatic finish
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by the dramatic falloff
by the dramatic substance
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com