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AS2O3-induced degradation of PML-RARA is initiated by the direct binding between AS2O3 and PML-RARA (Jeanne et al., 2010).
This model is strongly supported by the direct binding of eIF3b to 40S ribosomes and to the isolated ribosomal protein rpS9e in vitro.
While the transcriptional activation of target genes is mediated by the direct binding of p53 to consensus sequences in their promoters, several mechanisms have been proposed for p53-mediated repression.
Despite having a CNBD, vertebrate EAG family channels are not regulated by the direct binding of cyclic nucleotides [16], [17].
Initially, Schönherr et al. [17] reported that the inhibition of hEAG1 by Ca2+ was mediated by the direct binding of Ca2+/CaM to the C-terminus (AA 707 726) of the channel.
Therefore, it is feasible that aggregation of the floating cells was initiated by the direct binding of LL-37 to the cell surfaces and allowed for interaction between LL-37 molecules on adjacent cells (Fig. 4B).
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As an example of controllably introducing defects, graphene nanoribbon sensors have been reported to have enhanced pH sensitivities by enabling the direct binding of ions to edge defects (Fig. 4a, b) [25].
Thus, we set out to identify the targets of Id inhibition by determining the direct binding partners of both Id and E proteins in ESCs.
Jang et al. reported that BMP2 stimulated ATF6 (activating transcription factor 6) transcription by enhancing the direct binding of RUNX2 to the OSE2 (osteoblast-specific cis-acting element 2) motif of the ATF6 promoter region.
We, therefore, initiated our study by first investigating the direct binding of SP-A to C. neoformans (H99).
Regulation of gene expression by dMyc occurs through the direct binding of dMyc to E-boxes in the promoter region of target genes (Gallant, 2009).
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by the direct invasion
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