Sentence examples for by the difficulty with from inspiring English sources

While SGs and PBs have been extensively studied from the perspective of their protein content and dynamics and progress has been made in understanding their role in translational repression, the study of native mRNA dynamics during translational inhibition has been limited by the difficulty with detecting native mRNA with single RNA sensitivity.

The use of synthetic oligonucleotides as new drugs for human therapy is hampered by their fast degradation in vivo caused by endogenous nucleases, and by the difficulty with which these polyanions cross membranes (8).

And before you get too upset with me, let me go on by acknowledging the difficulty with doing this.

The strong point of this way of thinking about objectivity is that none of the threats discussed in the main body of this article threats posed by the difficulties with the "view from nowhere", with the value-free ideal, and with biases and idiosyncrasies in science puts scientific objectivity at risk.

As demonstrated by these experiments, the difficulty with working with serum alone, resulting in marginally detectable levels of particle precipitation even over a prolonged period of time, reflects the inherent complexities and ambiguities involved.

"The difficulty with inquiries by the varied parties that are being challenged, or whose practices are being investigated, is always less than optimal," she said.

This discrepancy is primarily caused by the difficulty associated with precisely defining the boundaries of each repeat copy (Bao and Eddy 2002).

For these students, any purported benefits of study group usage were eclipsed by the difficulty associated with forming or joining a group.

Previous work has led to some inferences about the effects of bulk bilayer properties on connexin channels [ 15, 62], although these studies were limited by the difficulties associated with working with preparations of native membrane or with cells.

One is how to process people fairly but quickly; the other, what to do with those who are rejected.Both tasks are made harder by the difficulty of knowing with any certainty where a refugee comes from.

The distance-one neighbor ring (R1) maintains the most diversity, which is easily explained by the relative difficulty with which any software variant would spread across this network.