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Overall, our study suggests that the differences in amount of DEGs found by the different platforms were mainly caused by differences in signal to noise ratios, and the numbers of observations between one and two-color platforms, when using the same number of arrays.
This, in part, maybe explained by the different platforms and analysis tools employed in these studies.
Our next goal was to determine whether over-representation of particular gene networks and canonical pathways could be found among the genes identified by the different platforms.
The apparently low overlap of CNVs detected by the different platforms might have several different causes.
Table 1A describes the origin of the RNA used to generate cDNA libraries sequenced by the different platforms, as well as the read number contribution of each.
We demonstrate significant overlap in the affected gene sets identified by the different platforms, although biological processes were represented by only partially overlapping sets of genes.
Similar(53)
The effective use of EA standards can provide cost and efficiency advantages by standardizing the different platforms, technologies, and application architectures among distributed sites (Boh & Yellin 2006; Ross et al. 2006).
It records all the events that happen across the different platforms used by salespeople, and identifies common threads.
We show here that the integration of the information captured by these different platforms results in a more comprehensive detection of differentially regulated genes and an enhancement of the apparent biological relevance of the findings.
Then using this information, we partition gene expression into different (independent) units and use this to identify genes relevant to clinical outcome as modulated by these different platforms.
We compared and contrasted the biological gene networks captured as being differentially regulated in AML versus ALL cells by the three different platforms compared with those captured by integrated analysis.
More suggestions(18)
by the different steps
by the different programs
by the different tools
by the other platforms
by the different conditions
by the different protocols
by the different combinations
by the different factors
by the different features
by the different techniques
by the different tissues
by the different tasks
by the different sectors
by the different samples
by the different categories
by the different levels
by the different shapes
by the different sources
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com