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The ploidy strategy that was most likely to be the most cost-effective (determined by the deterministic sensitivity analysis) was chosen as the best ploidy strategy.
A comparison of the Papanicolaou smear strategy to the ploidy 4 cell strategy (the best ploidy strategy determined by the deterministic sensitivity analysis) yielded ICERs primarily in the northeast quadrant of the cost-effectiveness plane.
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A base case that is defined by the mean value of the assumed scenarios for the AVD responder rate and the first year AVD costs was simulated in order to build the basis for performing the deterministic sensitivity analyses.
Probabilistic sensitivity analysis (PSA) was performed considering the uncertainty surrounding all parameters simultaneously [13, 33, 44, 55, 65] complementing the deterministic sensitivity analyses.
The probabilistic sensitivity analysis confirms the results of the deterministic sensitivity analysis.
The deterministic sensitivity analysis was based on incremental net benefit, which was calculated as the incremental QALYs multiplied by the willingness-to-pay threshold, minus incremental costs.
The results of the deterministic sensitivity analysis are summarized in Table 2, scenarios 2 13.
For most scenarios in the deterministic sensitivity analysis, the ploidy 4 cell strategy was the only cost-effective strategy.
32 In all the deterministic sensitivity analyses, anidulafungin was the dominant treatment compared with micafungin and caspofungin.
The results of the second deterministic sensitivity analysis are similar to those presented in the first.
The results of the univariate deterministic sensitivity analysis are summarised in Table 4.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com