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Functional attribution was made by the database SOURCE (http://source.stanford.edu) [80].
Functional classification was made by the database SOURCE (http://source.stanford.edu) [57].
For consistency, we used in our analysis the species names as provided by the database source.
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Gene product details are supplied by the source database and include the symbol, full name, synonyms and database ID; if a sequence is available, this will be displayed along with information parsed from the FASTA headers.
Some cases for which open full texts were found they were discarded from the sample altogether, if it was obvious that the item was not a peer reviewed scholarly article or that it was misclassified by the source database and clearly belonged to another discipline.
Although not taken into account when matching reactions, the direction of a reaction and the compartment(s) as indicated by the source database are shown in a C2Card.
In cases where a valid interaction detection method was not specified by the source database, the interactions are assigned to 'unknown' method and consequently given a poor score.
To prevent this, each Pubmed ID supporting an interaction was first associated with unique experimental methods and interaction types as provided by the source database.
Briefly, for each protein referred to by the source database, a protein sequence is retrieved, and assigned a hash code called a SEGUID by using the Secure Hash Algorithm (SHA-1).
But these filters are unfortunately not as reliable as one would want them to be, because the expected information is often either missing or not properly mapped onto the corresponding terms of the PSI-MI ontology, by the source database.
Written informed consent was not obtained from patients as it was not required, since a unique ID was allocated to each patient to replace identifiable personal information by the source database administrator before analysis, and also since it was specifically waived by the Institutional Review Board.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com