Sentence examples for by the current mutations from inspiring English sources
All results demonstrated that TEVp is not engineered to embody the most desirable solubility and stability by the current mutations.
The estimated mutation rate during DNA replication in eukaryotic cells is lower than 1 mutation every 10 bases [23], which would be undetectable by our current mutation assays.
One, test data that kills all mutants generated by current mutation tools can still miss detection of some common logic faults because such tools lack appropriate logic mutation operators.
An example of germline MMR gene mutations that would be undetected by current mutation testing approaches of Sanger sequencing and MLPA includes a mutation deep within intron 1 of the MSH2 gene (c.212-553_c.212-479) in a single family with multiple colorectal cancer-affected individuals that demonstrated loss of expression of MSH2 and MSH6 by IHC.
There were three possible explanations: (1) these patients might have other non-classical or mosaic/somatic mutations that could not be detected by current mutation screening methods; (2) these patients might have mutations in unknown genes; (3) these patients might be acquired ISIP without mutation.
The introduction of the parental isolate NRRL1951 in our analysis revealed a number of mutations inherited by the current international laboratory standard strain Wisconsin 54-1244 during the first period of CSI.
In agreement with evolutionary models of aging, our results suggest that cancer is not rate-limited by the occurrence of oncogenic mutations as postulated by the current model of carcinogenesis, but its incidence instead is tightly linked to the evolution of lifespan and is promoted by altered selective value of oncogenic mutations that accumulate over lifetime in aged tissues.
In seven cases (comprising respectively 3.8%and2.7%7% of all RIF and INH phenotypically resistant isolates) "wild" type hybridization patterns in relevant genes were registered in DNA samples extracted from sputum specimens which then produced resistant M. tuberculosis cultures probably indicating the presence of less common mutations not detected by the current version of the MTBDRPlus assay.
This overrepresentation does of course reflect the importance of exonic sequences in splicing regulation, but may also in part be caused by the current routine mutation detection techniques, where intronic sequences are not analyzed.
By contrast, under the current assumption that mutation rates vary proportionally to CDS length, the expected gene numbers better fitted the experimental results.
