These contradictory observations can be reconciled by the observation that the concurrent expression of synthesizing and degrading enzymes has the strongest impact on tumor growth and metastasis, suggesting that increased synthesis coupled to turnover of HA is decisive in this context.
Although we cannot exclude the concurrent expression by the same parasite of additional SVSPs, our initial findings indicate that the expression of individual SVSPs may be restricted.
10– 13 We then validated the concurrent expression of the oncogenic miRNA 17-92 in RB patient serum samples by using quantitative real-time PCR.
Further research is needed to determine if the concurrent expression of these genes is related.
Moreover, GR-mediated transcriptional regulation can be modulated by posttranslational modifications or by concurrent expression of dominant negative splice variants and other isoforms.
While Tregs are easily defined in mice by concurrent expression of FOXP3 and high levels of CD25, in humans CD25 cannot be clearly delineated into low and hi expressing subsets due to a continuum of expression.
These data suggest that MIA2 might act as a protumoral factor that was influenced by concurrent expression of MIA, receptor integrin expression patterns, and activation pattern of MAPK family in OSCC.
Moreover, in both models, the induction of fat Cnr2 expression was correlated with adipose tissue inflammation, as shown by the concurrent increase in the expression of Emr1, encoding the macrophage related marker F4/80 (Fig 1A).
Interestingly, in the study by Korkolopoulou et al., concurrent expression of CD95, CD95L and c-FLIP was observed in 22 cases, suggesting a function of c-FLIP in protecting the tumours against CD95-mediated apoptosis.
Up to 88% of expressed protein coding loci displayed concurrent expression from the complementary strand.
