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Reasonable agreements are obtained between the predictions by the computational analyses and the existing experimental measurements.
The vast majority of the genomics data deposited in our databases is public data downloaded from the major repositories (GEO, ArrayExpress, and UCSC Genome Browser), or produced by the computational analyses of genomics data (e.g. computationally predicted transcription factor binding sites).
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While the reviewers and editors acknowledge the importance of the topic they remain concerned about the design of the study itself (articulated by Reviewer 1) and the extent of advance from the computational analyses (as discussed by Reviewer 2).
Validation of the computational analyses was performed by comparison with previously published expression data, in situ hybridizations, promoter-reporter fusions, and reverse transcription PCR.
The computational analyses were carried out by using an impulse load, which excited the structure, and a piezoelectric transducer, which measured the output data.
D.N. and P.B. performed the computational analyses.
F.G. performed the computational analyses and drafted the manuscript.
A.S. and F.S. performed the computational analyses, and U.U.-U.
M.R. designed and performed the computational analyses, and analysed the data.
RX performed the computational analyses.
SA carried out the computational analyses.
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