Sentence examples for by the combinatorial modification from inspiring English sources

This complexity in histone modifications might not only be seen as a simple code, but rather as an ingenious chromatin 'language' where different biological outcomes are defined by the combinatorial modification of basic building blocks [13].

By a combinatorial modification of four key residues within the coenzyme binding sites, different GAPDH mutants with varied coenzyme specificity were constructed.

The extension of the synthetic methods to combinatorial modification of conductive polymers is also discussed.

Though proteoform complexity is high, it seems nowhere near theoretical limits based on the simplistic 2n scaling from combinatorial modification (where n is the number of PTMs).

This first point is strongly supported by the profusion of possible promoter states provided by the combinatorial patterns of histone tails modifications and nucleosome positioning [ 60- 64] and the alternate compositions of multiprotein complexes found on promoters [ 53, 54].

However, because chromatin states are often dictated by combinatorial histone marks and each histone also has its specific implications, we explored the combinatorial histone modification variations across all TFs.

DNA and histone modification maps obtained from numerous genome-wide chromatin immunoprecipitations studies and the identification of histone codes by MS demonstrate that DNA and histone modifications form combinatorial modification patterns within chromatin.

Additionally, given that we evaluated single-point mutants, the impact of combinatorial modifications in the substrate could not be readily assessed from our approach.

Binding signals resulting from the same sequence were extracted from the microarray and the effects on coexisting (combinatorial) modifications in the H3 tail were assessed.

Each combinatorial modification is observed in a single histone tail by tandem mass spectrometry.

The spatial and temporal pattern of activity of an enhancer is controlled by the type of epigenetic modifications attached to it, and by the combinatorial binding of transcription factors to specific binding sites in the enhancer's sequence [ 1].