Sentence examples for by the canonical loop from inspiring English sources

The antiprotease site is primarily formed by the canonical loop stabilized by the Cys14-Cys38 disulfide bond: about 8 amino acids surrounding the P1 residue (residues positionsositions 12 19 in BPTI) are in direct contact with the protease.

Strategies to re-engineer serine protease inhibitors commonly focus on the active site binding β-sheet of the canonical loop.

Producing potent and selective standard mechanism inhibitors depends on fully realizing the highly conserved and successful structural features of the canonical loop.

More generally, one might step outside the framework of canonical, loop quantum gravity, and ask why one should only quantize the metric.

While the importance of canonical loop rigidity is well appreciated in naturally occurring structures, it has not received similar attention when modifying these inhibitors for new targets.

While designing the circuit the idea is to reduce the diagram to its canonical form because the canonical feedback loop is the simplest form of a feedback loop.

The idea is to reduce the diagram to its canonical form because the canonical feedback loop is the simplest form of a feedback loop, and its analysis is well documented.

The prominent role of internal hydrogen bonding in maintaining canonical loop rigidity is not only limited to the SFTI scaffold.

However, the conformation of the glycine-rich loop differs from the canonical P-loop structure and the biological significance of the in vitro RNase activity remains controversial [ 34].

The fact that the conformation of the canonical binding loop has evolved numerous times independently highlights its versatility as a starting structure for inhibitor design.

Recent biochemical, structural, and genomic mapping studies highlight several lines of evidence that challenge the canonical feedback loop model.