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Further, we analyze the hierarchical organization of the network components of the B-cell gene regulatory network as revealed by the bootstrap approach.
A phylogenetic tree was constructed by the neighbor-joining method (20 ), and the reliability of branching orders was tested by the bootstrap approach (21 ).
Phylogenetic trees were constructed by the neighbour-joining method and reliability of the branching orders was assessed by the bootstrap approach with CLUSTAL W. A nucleotide sequence was assigned to a HPV type if it displayed greater than 90% homology with this type (de Villiers et al, 2004).
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Bias-corrected 95% CIs for correlation coefficients were estimated by using the bootstrap approach.
Empirical 95% confidence intervals (CI) and flanking markers for estimated QTL positions were obtained by applying the bootstrap approach with 1000 re-samplings [ 27].
Finally, the sampling variance of the estimated U XY can be empirically determined by the bootstrapping approach or a simple approximate method.
This leads to an accurate semi-analytical error probability due to the bootstrap approach efficiency.
The bootstrap approach is based on the assumption that the bootstrap distribution is similar to the sample distribution.
The motivation behind the bootstrap approach is to avoid genes with large bootstrap confidence intervals.
One frequently used method is the bootstrapping approach suggested by Austin and Tu [ 35].
The validity of this model was assessed by the parametric bootstrap approach using the sum of the squares of the deviations between observed and expected mismatch distributions as a statistic as implemented in ARLEQUIN.
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