A mutated catalytic domain (DAPKdel) missing a portion of the basic loop sequence was made by excising the amino acid sequence SRRGVS between S52 and S57 (see Figure S2).
Taking Drosophila sensory organ formation as an example, the position of the sensory organ precursor (SOP) is determined by the basic helix-loop-helix (bHLH) transcription factors of the Achaete-Scute complex (AS-C) [16].
Geminin binds to Brg1, the catalytic (ATPase) subunit of a SWI/SNF chromatin remodeling complex, and inhibits its recruitment to neuron-specific promoters by the basic helix-loop-helix (bHLH) transcription factors Neurogenin (Ngn) and NeuroD [7].
This sequence of expression is followed by the basic helix-loop-helix, pro-neural gene NeuroD and the Tbr2-related layer VI marker, Tbr1 (Hevner et al., 2006).
The largest gene family was the ethylene-responsive element binding factor family (ERF), followed by the basic helix-loop-helix family (bHLH), C2H2 family, the Homeodomain-leucine zipper family (HD-ZIP), and the WRKY family.
In the in vitro study presented here, we describe the homodimerization of DAPK catalytic domain and the crucial role played by its basic loop structure that is part of the molecular fingerprint of death protein kinases.
The gp64 basic loop is contained within a 519 bp fragment flanked by Narl and Sapl sites.
One large superfamily of TFs characterized by the basic-helix-loop-helix (bHLH) DNA binding and dimerization domain is critical for development in almost all eukaryotes (Jones 2004).
Furthermore we uncovered a lipid binding property which is mediated by a unique extended basic loop between blades 6 and 7 of the propeller.
Some of the vendors have made part of basic loop parameters configurable by the users, but, in general, they are unwilling to disclose more details about their signal-processing algorithms and how the measurements are actually made.
