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While there is no theoretical limit to the size of a compound that can in principle be represented using CHESS, our sample implementation is practically limited (by the available computational resources on the server) to lower molecular weight compounds.
For reasons related to storing the similarity matrices, the similarity threshold evaluation began at t = 0.30 in the case of the WOMBAT and MLSMR datasets, to assure that the produced networks can be stored and processed by the available computational tools.
These analyses are often limited by the available computational resources.
However, the size of the dataset analyzed in WEKA may be limited by the available computational memory and has to be taken into account.
Here, we have analysed the Giardia genome for the probable S/MARs predicted by the available computational tools; and then shown these sequences to be physically associated with the nuclear matrix.
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The PM_CMPS methodology constructs a prior distribution using all of the available computational and experimental information, by relying on the maximum entropy principle to maximize the impact of all available information and minimize the impact of ignorance.
The complete independence of each analysis permits extensive parallelisation depending on the available computational resources.
The amount of data increases in lockstep with computational efficiency multiplied by the amount of available computational resources, which shifts the bottleneck in the scientific process from data acquisition to data processing and analysis.
The highly available computational services are provided by the Heartbeat program of the Linux HA project (http://www.linux-ha.org).
Though initially intended as a local pipeline management tool, Ergatis has been extended and employed by some users to drive publicly available computational web resources.
These community-wide exercises provide stringent tests of available computational methods by challenging modelers to predict structures of ncRNA sequences that have been crystallized but whose structures have not been publicly released.
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