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This was strongly influenced by the array design, including array structural and environmental factors, such as module spacing and ground cover, respectively.
We found that our method based on the empirical data is limited by the array design.
This success rate, which is much higher than expected, is likely driven by the greater than expected presence of naturally occurring variation in effective ploidy level within polyploid individuals, as well as by the array design employed and SNP genotyping strategies.
Similar(57)
We anticipate that by improving the array design and adding the complementary strand for each probe, the FDR will be reduced as suggested by Smemo et al [ 37].
Errors due to low sequence similarity can be avoided by basing the array design on reference genomes from strains in different branches of the phylogenetic tree of a species.
The performance of space time codes may be severely affected by the scattering richness, the array design, or the presence of coherent components.
A custom produced array design can be created by directly uploading layout definition files from spotting robots (e.g. Microgrid II or GMS), hence avoiding error-prone manual entry of the array design.
The array designed by Boyer et al. covered the -8 kb to +2 kb region relative to each transcription start site of 18,002 transcription start sites representing 17,917 unique genes.
This restriction imposed by the current array design constrains the upper detection limit and therefore also imposes a limitation on the linear range of detection: highly abundant genes can lead to rapid saturation of the signal and to significant signal overspill when differing by over 3,000-fold 3,000-foldty from the neinhbourintensity
In this study, due to the high statistical reliability imparted by the high replicate probe count (n = 18 to 30) enabled by the custom array design, we chose to compare the results of 3 different approaches to the intact dataset but modeled as either all data or individual tumor types.
Some preliminary experiments with different solvents in combination with water, acetic acid and ammonium hydroxide, were developed in order to design the predefined region covered by the orthogonal array design used for optimization.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com