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This migration defect was partly caused by the abnormal migration of bipolar cells in Dpy19l1-knockdown brains.
These results suggested that the defective migration in Dpy19l1-knockdown brains was caused, in part, by the abnormal migration of bipolar cells.
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We determined that the abnormal electrophoretic masses of the TRP47 were associated with the highly acidic TR domain, suggesting that the abnormal migration is due to acidic nature of the TRs within these ehrlichial TRPs [9], [44].
The reason for the abnormal migration behavior of the atypical fragments remains to be determined.
We agree with this reviewer that ectopic presence of Tbr2+ cells in the EGL and ML of the Nf1Math1CKO cerebellum could be caused by abnormal migration of Tbr2+ cells from the RL.
To investigate if these phenomena are caused by abnormal migration due to the absence of LRP1, we performed two different kinds of in vitro migration assays.
Notably, srGAP3 knockout mice exhibit perinatal-onset hydrocephalus, which is possibly due to cerebral aqueductal occlusion caused by abnormal migration and differentiation of progenitor cells from the ventricular region into the corpus callosum [ 181, 183].
This observation argues against the possibility of abnormal migration of Tbr2highNeuN− UBCs into the EGL.
In addition, abnormal migration of the C813R mutant protein was observed in gel electrophoresis.
RNA interference of Marlin-1 in vivo results in abnormal migration of newborn pyramidal neurons during the formation of the cortex.
The ring heterotopias also appeared to represent abnormal migration of neurons, glia and other unidentified cells.
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