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Instead, they're spread by the abnormal folding of naturally occurring and normal prion proteins in our brains.
And the PRNP is a pathogenic protein caused by the abnormal folding of proteins.
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It is made clear that the abnormal folding phenomenon occurs only in certain combinations of design parameters.
Transmissible Spongiform Encephalopathies (TSEs) are a group of progressive fatal neurodegenerative disorders, triggered by abnormal folding of the endogenous prion protein molecule.
Furthermore, an abnormal folding of the postsynaptic apparatus of the neuromuscular junction was noted [ 1].
Our findings provide new insights into the molecular mechanisms underlying the formation of iPrPC and abnormal folding of mutant proteins.
Cystic fibrosis (CF) or mucoviscidosis is a multi-system monogenetic disease caused by mutation of the cystic fibrosis transmembrane regulator (CFTR) gene leading to abnormal folding and function of the CFTR protein, which is a chloride/bicarbonate channel.
Proteins fold into the correct three-dimensional structures with the assistance of chaperone proteins to avoid abnormal folding and aggregation [ 1].
The diseases are infectious, most researchers think, because PrPSc has the peculiar ability to impose its abnormal folding on PrPc.
It can be impossible to identify abnormal folding patterns, particularly by radiology, before this time.
The bh20 and bh23 mutations also cause abnormal folding of gonad arms and subtle uncoordinated phenotypes (data not shown).
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