These results suggest that the abnormal dendritic spine morphology in Cln1 −/− mice is appreciable in these mice around 6 months of age when they manifest signs of synaptic dysfunction attested by myoclonus and seizures.
Mice hemizygous for the deletion showed several behavioural and cognitive deficits accompanied by abnormal dendritic arbourization in the hippocampus.
99, 100 The observations of abnormal dendritic spine morphology 115 and increase in synapses lacking AMPARs 104 in Ube3am-p+ Ube3am-p+with this hypothesis.
We suggest that the PrPd accumulation on the plasmalemma of FDCs is linked with the activation of both abnormal dendritic folding and excess immune complex retention.
Loss of FMRP in humans causes fragile X syndrome (FXS), characterized by autistic behaviors, childhood seizures, abnormal dendritic spines and macroorchidism in male patients.
This mouse recapitulates a number of pathological features of the Fragile X Full Mutation, such as macroorchidism and abnormal dendritic arborization in the brain.
In addition to morphological changes (cytomegaly, abnormal dendritic arbors, and the loss of radial orientation), DNs are characterised by the aberrant expression of neuronal and glial markers with a prevalently neuronal-mature identity.
The surviving neurons in tubulin-labelled otd null ALl1 clones manifested abnormal dendritic projection patterns in the antennal lobe.
This results in an impaired photoreceptor synaptic transmission, an abnormal dendritic branching of neurons postsynaptic to photoreceptors, and the formation of ectopic synapses.
To illustrate the findings of Figures 2E and 2F: Raw data examples showing abnormal dendritic node and filopodia formation upon Rac1 overexpression.
