Sentence examples for by the abnormal activation from inspiring English sources

Figure 5 demonstrates that the suppressive effect of mature α/β TCR transgenes on DN cell proliferation is mediated by the abnormal activation of PKD2 catalytic activity.

Further experiments suggested that the reaction was caused by the abnormal activation of certain genes in the iPS cells, resulting in the production of proteins that seemed foreign to the immune systems of the mice.

Currently, no ideal treatment for ALCL caused by the abnormal activation of ALK and its downstream signaling pathways is available.

Our finding offered the convincing evidence that SAHH inhibitor DZ2002 might attenuate psoriasis by simultaneously interfering the abnormal activation and differentiation of keratinocytes and accumulation of IL-17-producing T cells in skin lesions.

The abnormal activation of microglia and the induced inflammation are a common link of the process which is caused by dopaminergic neuron damage.

The mechanisms may rely on the abnormal activation of VEGF pathway.

Accordingly, the abnormal activation of glycogen synthase kinase-3-beta (GSK3β) can reduce neuronal viability [ 20].

Furthermore, it has been reported that the abnormal activation of Cdk5 is involved in neurodegeneration.

This possible mechanism was explained therein according to an excessive sympathetic reaction, causing an opposite reaction to the initiated by an abnormal activation of mechanoreceptors activation, and also causing the activation of the afferent vagal fibers.

Autoimmune diseases may be initiated by malfunctioning lymphocytes whose apoptotic pathways, normally activated by self-antigens, are blocked by abnormal activation of NF-κB, enabling the survival of self-reactive cells [ 21, 127- 130].

TTP is caused by a hereditary (genetic) or acquired (autoantibodies) ADAMTS13 deficiency, whereas aHUS is caused by an abnormal activation of the alternative complement pathway due to defective regulation of specific complement factors [ 50, 61– 63].