Sentence examples for by the aberrant expression from inspiring English sources

Targeted protein degradation using the PROTAC technology is emerging as a novel therapeutic method to address diseases driven by the aberrant expression of a disease-causing protein.

The cellular consequences of HuR's dysfunction were underlined by the aberrant expression of selective cell cycle regulators, TCR, and death-receptor signaling components.

Many cancers metastasize to specific organs, what frequently is caused by the aberrant expression of GPCRs in cancer cells - especially chemokine receptors - concomitant with the release of chemokines from the secondary organs [6].

Leukemogenesis resulting from chromosomal translocations of the MLL1 gene is characterized by the aberrant expression of Hox genes, a process dependent on the interaction of the MLL fusion protein with menin [9].

The results described above indicate that the genome instability caused by the absence of menin and heat stress cannot be explained by the aberrant expression of Hsp70 (Fig. 3).

BRCA1 expression in colon cancer might be affected by the aberrant expression of BARD1.

Specifically, alcohol induces oxidative stress in the lung at least in part by inducing the aberrant expression of TGF β1 expression which in turn suppresses Nrf2 expression and interferes with its ability to activate the ARE.

The enhanced uterine estrogen response was further evidenced by the increased epithelial proliferation demonstrated by Ki67 staining and the aberrant expression of the phospho-estrogen receptor α (p-ERα), while the serum level of 17β-estradiol (E2) and the expression of ERα did not show obvious changes (Supplementary information, Figure S6A and S6D).

On the basis of these findings, here we have explored potential epigenetic cross-talk triggered by PGE2 responsible for the aberrant expression of IL-8 in human astrocytoma.

In correspondence, the relative sensitivity of TCF3-rearranged leukemic cells for Ibrutinib without need for external stimuli other than those provided by the culture medium and the aberrant expression profile of pre-BCR-related proteins suggests that the pre-BCR pathway is more activated in TCF3-rearranged compared with non- TCF3-rearranged leukemic cells.

We illustrate Messina by using it to detect the aberrant expression of a gene that may play an important role in pancreatic cancer.