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Sensitivity analysis that adjusted for length of FU by testing the term "age*length of follow-up" revealed that length of FU did not significantly affect the significant relationship between age and postoperative periprosthetic fractures after primary TKR.
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Markov's principle represents an unbounded search: if you have a proof that all terms an being 0 leads to a contradiction, then, by testing the terms a1,…2,a3,… in turn, you are "guaranteed" to come across a term equal to 1; but this guarantee does not extend to an assurance that you will find the desired term before the end of the universe.
Homogeneity of slopes was assessed graphically and by testing the interaction term treatment*PTA_T1 in a preliminary model.
We also tested possible non-linear associations by dividing the exposure variables in splines and by testing the quadratic term of the variables in the regression models.
We then evaluated the difference in prognostic value of a given gene for the two subtypes by testing the interaction term between gene expression and subtype in a Cox regression model.
In addition, analyses of variance (ANOVA) were performed to determine whether there was an additive vs synergistic effect in Figure 4 by testing the interaction term between MTX and ALA-PDT.
We assessed the proportional hazards assumption by testing the interaction terms of the factors listed in Table 2 with time.
In an explorative analyses we will assess whether the risk of cardiovascular and neuropsychiatric events differ according to sex, by testing the interaction terms in the Cox models between medication use and sex.
We checked the proportional hazards assumption by the Kolmogorov-type supremum test, as implemented in the PROC PHREG procedure of the SAS package, and by testing the interaction terms between follow-up duration and the internal dose of cadmium.
Whether there were changes in the differentials of indicators by wealth terciles between the survey periods were determined by testing the interaction terms between survey periods and wealth tercile indicator variables using a logit model.
The assumption of proportional hazards was examined by testing the cross product terms between covariate variables and log function of survival time, and P values for all the terms were >0.10.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com