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We attempted to replicate the genetic association in ABAT using an adult Swedish GERD case-control cohort by testing the associated ABAT SNP together with surrounding SNPs but found no evidence for genetic association.
As above, we characterized the nature of the 3-way interaction by testing the associated simple interactions, confirming it was also driven by CS+ trials (Fig. 4 C ).
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Second, we utilized a hypothesis-free approach by testing the association of the most strongly associated AMH SNP with 2528 traits or diseases in a sex-combined cohort from the deCODE study (45), with a maximum trait sample size of 104 220.
We first examined whether uPAR and β1 integrin were physically associated by testing the ability of anti- β1 antibody to coimmunoprecipitate (co-IP) uPAR and of uPAR antibody to co-IP β1 integrin from cell lysates.
In this study we analyzed MSP1a repeat and microsatellite sequences in order to provide information on the evolution of A. marginale strains by determining their phylogeographic association with world ecological regions (ecoregions) and by testing the effect of different evolutionary pressures associated with the tick vector, mainly R. microplus, ecology in these ecoregions.
We also investigated if the balance between pro-apoptotic and anti-apoptotic proteins was associated with DSS by testing the impact of Bcl-2/Bax and Bcl-XL/Bax ratios on survival outcome.
We will check to see whether refusal or losses to follow-up is associated with sociodemographic characteristics by testing the statistical significance of differences between refusals and consenters, and those lost to follow-up versus those retained at 6 months in terms of age, sex and level of education.
We also describe the performance of the new measure by testing whether comorbidity is associated with increased mortality in a cohort of patients from the GPRD.
An example of an integrated approach to identify lifespan regulating loci is represented by testing whether genetic variants associated with potential biomarkers also associate with longevity.
The significance of the differences between the predictive spectral models tested was assessed by comparing the associated AUC values using ANOVA or t-test when appropriate.
Tsai et al. (2005) [ 9] integrated ChIP-chip data and gene expression data to identify synergistic TF pairs by testing whether they are associated in the same gene more often than random expectation.
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