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This was done to examine change over time by testing interactions between SHC and time.
The proportional hazards assumption was examined by testing interactions between the genotypes and time (all P-value > 0.05).
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Logistic regression was used to estimate associations between stressful life events and both MD and AD; sex-specific effects of stress on MD and AD were evaluated by testing interaction terms between sex and stressors in the prediction of both outcomes.
We tested interactions between variables by including interaction terms.
Because the study in Guatemala was an intervention trial, we checked for heterogeneity of effects on outcomes between the intervention and control arms of the trial by testing for interactions between early-life weights and intervention group.
Significant differences were evaluated by testing for interactions between the subgroup categories and treatment effect in the regression model.
Formal testing for differences in the intervention effect among counties is possible by testing for interactions between county and intervention group in the regression analyses described below.
Finally, we tested for evidence of the constant risk fallacy by testing for interactions between the centre and each predictor variable in the model individually against outcome (death at seven days) to investigate whether the risk for a given factor was constant across centres, as evidence of interactions indicates that risk is not constant between centres.
This can be accomplished by manipulating the genomic region containing the SNPs in question and determining if expression of the putative target gene is in fact altered and/or by testing physical interactions between the region harboring the SNP and a putative target gene using looping assays.
Although the major question of this study focuses on the intensity of psychotherapy for depression, this study will additionally explore whether the effect of treatment intensity differs between IPT and CBT by testing an interaction between treatment conditions.
By testing for interaction between the effects of surgery and strain, we identified 249 "interaction genes" whose expression was affected by post-pubertal testosterone differentially according to the genetic origin of chrY.
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