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In adult animals, miR-17∼92 and miR-106b∼25 have been shown to influence the functionally intertwined pathways of apoptosis and G1/S cell cycle progression by targeting multiple components of each pathway [20].
This is consistent with numerous studies suggesting that miRNAs regulate cellular pathways by targeting multiple components [ 48].
By targeting multiple components of the antigen receptor signal transduction machinery for degradation, Cbl and Cbl-b serve as negative regulators of antigen receptor signaling.
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Interventions with combinations of messages targeting multiple components of practice had an impact on one component, but not all components targeted.
Altogether these events highlight the therapeutic advantage that targeting multiple components of the EGFR/Src/cortactin axis could represent.
However, it is known that individual microRNAs can target multiple components within one signaling pathway.
Hypoxia-induced autophagy results in upregulation of miR-155 that targets multiple components of mammalian target of rapamycin signalling.
Gaitanos et al further demonstrated that a more complete depletion of the Ska complex from HeLa cells, achieved by targeting multiple Ska complex components through RNAi, resulted in severe chromosome alignment defects, stemming from an inability to form stable kinetochore microtubule attachments.
miR-146a thus inhibits the type I interferon production by simultaneously targeting multiple key components of the induction pathway.
A multi-component community based intervention, targeting multiple outcomes, and delivered by trained lay health workers, supervised by mental health specialists, is an acceptable and feasible intervention for treating schizophrenia in India.
(1) Present a broad AutoTutor question that targets multiple knowledge components (KCs) associated with a topic.
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