Sentence examples for by targeting cell surface from inspiring English sources

With the chip-based biosensor, cancer cells were detected by targeting cell surface markers.

The fact that CD44+ HL and MCL cell lines were sensitive to anti-CD44 induced apoptosis may allow for new therapeutic strategies by targeting cell surface CD44.

(2) RNA can target specific cell groups by targeting cell surface receptors through the use of RNA aptamers that function like protein or chemical ligands.

Fortunately, our data demonstrate that an effective sialidase inhibitor can confer protection by selectively targeting cell surface Neu1, perhaps by virtue of poor drug accessibility to the intracellular compartment.

IFNs are already being used to treat most hepatitis patients, and their effects suggest targeting cell surface molecules induced by IFN may be a useful strategy for treating HCC.

Chemokines mediate their activities by binding to target cell surface chemokine receptors that belong to the large family of G protein-coupled, seven transmembrane (7 TM) domain receptors (also called serpentine receptors) (3).

The ability of exosomes to interact with cells may be due to several potential mechanisms, including direct cellular contact, which is mediated by the interaction of exosomal membranes with target cell receptors, the binding of exosomal membrane proteins released by protease-mediated cleavage to target cell surface receptors, and endocytosis by fusion with target cells [ 5, 10].

Here we uncover a herpesvirus protein that acts to inhibit TRAIL-mediated apoptosis by specifically targeting cell-surface expression of the TRAIL DRs. HCMV now joins a growing list of DNA and RNA viruses that modulate signaling by the TRAIL/TRAIL-R cytokine system.

To further demonstrate the impact on immune response efficiency elicited by respective target cell surface antigen profiles, the number of viable target cells surviving cytotoxicity assays was plotted against profile correlation values calculated pairwise for target HMEC and HMEC used to generate antigens (EAA) for eliciting immune response in the cytotoxicity assays.

C3, whether synthesized locally or deposited onto stressed cells by circulating C3, is cleaved on the target cell surface to form the C3b fragment and then further degraded into the membrane anchored C3dg and C3d fragments which remain covalently bound to the cell.

Recognition of specific antigens in the form of peptide-MHC class I complexes (pMHCI) presented on the target cell surface is mediated by T cell receptor (TCR) engagement.