Sentence examples for by systemic side effects from inspiring English sources

PDE4 inhibitors are a validated approach as anti-inflammatory agents but are limited by systemic side effects including emesis.

Prostaglandin E2 and related EP4 receptor agonists have been shown to stimulate bone regrowth but their use has been limited by systemic side effects.

Despite high oral bioavailability, the anti-spasmodic efficacy of baclofen is limited by systemic side effects, necessitating a targeted approach.

Exogenous glucocorticoids have a dramatic effect on synovial inflammation but their use is limited by systemic side effects.

The conventional therapeutic strategies for myeloid leukemia are limited by systemic side effects, development of chemoresistance, and poor survival outcomes.

Aromatase inhibitors are effective in enhancing patient survival although long-term use is limited by systemic side effects and therapy resistance [ 47].

However, the dose is limited by systemic side-effects and this might explain why CSIs occurred despite the presence of nimodipine.

In contrast, interferon (IFN -α or pegylated-IFN -αtreatment can result in virus clearance, but its efficacy is limited tora proportion of patients and is accompanied by systemic side-effects [ 13].

However, systemic delivery is limited by significant systemic side effects, short plasma half-life or poor blood-brain barrier passage.

Although the class of mTOR inhibitors seems to be relatively well tolerated and offers exciting new therapeutic opportunities in different disorders, they are accompanied also by local and systemic side effects and adverse events.

The use of molecular cancer therapeutics is often limited by life-threatening systemic side effects due to high drug dosage and non-site-specific targeting [32].