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Alvarez-Erviti, L. et al. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes.
Surprisingly, galanin significantly attenuated the reduction of hippocampal 5-HT release induced by systemic injection of the 5-HT1A receptor agonist 8-OH-DPAT.
In line with the behavioral data, LDTghM3→VTA mice submitted to SubSD showed enhanced excitability of VTA DA neurons when injected with CNO but not saline, an effect that could be reversed by systemic injection of mecamylamine (Fig. 4c).
We next investigated the effect of stimulation of the lacrimal function by systemic injection of a muscarinic cholinergic agonist pilocarpine.
Recently, in a model mimicking a maternal viral infection, the behavioral alterations in the progeny were prevented by systemic injection of blocking antibodies against interleukin-6 [5].
AgApoLp-III expression was silenced by systemic injection of dsRNA, and endogenous mRNA levels were reduced by 78% to 90% (Figure 5A).
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Five cats were deafened by systemic injections of neomycin sulfate (60 mg/kg, SQ, SID) starting one day after birth, and continuing for 16 18 days until auditory brainstem response (ABR) testing demonstrated profound bilateral hearing loss.
Here we describe activation of microglia in the rat spinal cord by systemic injections of toll-like receptor agonist polyinosine polycytidylic acid (poly(I C), a TLR3 ligand) and R848 (a TLR 7/8 ligand).
In surviving mice, the syndrome includes inflammation of the exocrine glands in a large share of the animals that can, however, be prevented by systemic injections of synthetic fibronectin peptides [ 112].
To determine whether we could image cells in vivo using this system, IQ-tag expressing cells were first implanted subcutaneously into nude mice, followed by a systemic injection of GH680 and imaging by fluorescence mediated tomography (FMT) (Fig. 6E).
Examples include exosomal delivery of small interfering RNAs to the mouse brain by systemic injection and exosomal delivery of let-7a to target epidermal growth factor receptor in RAG mice.
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