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Hyperalgesia on intradermal capsaicin application can be attenuated by systemic application of local anesthetics.
In this study, we evaluate procognitive properties of 3α5β-P-Glu in an animal model of schizophrenia induced by systemic application of MK-801.
Mini-agrin was also successfully delivered to skeletal muscles by systemic application of adeno-associated viral vectors (Qiao et al, 2005).
These experiments also showed that NMDA-R blockade, by systemic application of MK801, prevented synaptic potentiation in DA neurons (Ungless et al., 2001).
Targeting of PRRs such as CD14, TLR4, and TLR2 in models of acute infection within which deliberate short term antagonism is achieved by systemic application of neutralizing mAbs has been shown to effectively inhibit unwanted immune responses [ 5- 7].
Moreover, beneficial effects of exon skipping in vivo were achieved by systemic application of vPMO-AONs, a chemistry that is currently under extensive investigation and is rapidly becoming safer and more efficient (Betts et al, 2012).
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This interpretation is supported by two other 2-DG studies where, in fact, distinctive columnar patterns of 2-DG consumption were observed in rat neocortex during more stable states of drowsiness as induced by systemic applications of irreversible alpha-adrenergic blockers (Savaki et al. 1982) and subanesthetic doses of Ketamine (Hammer and Herkenham 1983).
Also it became clear that a mild oxidative stress by sport may delay aging which is abolished by the systemic application of N-acetylcysteine.
Unlike in systemic genetic disorders where one might want to transfect a majority of target cells of an individual by a systemic application of a gene formula, in the case of tissue repair or regeneration only a local effect is required and desired.
By contrast, repeated systemic application of sgp130 after onset of AIA only slightly attenuated pain at a late stage of AIA.
Discrepancies were shown by means of a systemic application of the mentioned standards to a specially instrumented prototype of professional oven.
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