Sentence examples for by sustained expression of from inspiring English sources

The reduced proliferation is accompanied by sustained expression of cyclin D and E, abortive S phase entrance and is dependent on Ras signalling deregulation, since it is rescued by expression of a dominant negative guanine nucleotide exchange factor.

In addition, TGF- β1-induced IEC-6 cells growth inhibition was partially reversed by sustained expression of miR-200b.

The acute inflammatory response to TNF-α subsided after several hours and was followed by an IFN response characterized by sustained expression of STAT1 and downstream target genes.

The identity of SKBR3 and EGFP-SKBR3 cells was further confirmed by sustained expression of epithelial cell adhesion molecule (CD326, ≥98% positivity) verified by flow cytometry with specific antibody anti-EpCAM-PE (Miltenyi Biotec GmbH, Germany).

Studies show that prolonged inflammation in diabetic wounds is characterized by sustained expression of proinflammatory cytokines, such as interleukin-1 (IL-1) and TNF-alpha, and large numbers of polymorphonuclear neutrophils and macrophages, which delay epidermidalization [ 32].

Like Dido3 mutants, GATA-4-deficient ES cells fail to differentiate after aggregation and LIF withdrawal, as shown by sustained expression of Oct4 and other undifferentiated stem cell markers; their ability to differentiate can be restored by retinoic acid.

29 Exhausted T cells are characterized by their sustained expression of inhibitory receptors such as PD-1 and Tim-3.

This indicates that the accumulation of H2O2 in the transgenic lines was likely to be caused by the sustained expression of the membrane-localisted StRboh.

The reduced miR-24 level in retinoblastomas relative to normal retinas may be explained by the requirement of sustained expression of proliferation genes in tumor cells while maintaining sufficient amounts of miR-24 to repress the ARF tumor suppressor.

The MS-275-pulse caused a slight decrease of the neuroectodermal marker Pax6 expression, accompanied by an earlier, and more sustained expression of Nestin (Fig. 3D).

Sustained expression of the transgene by the injected cells was demonstrated by the green fluorescent signal of cells transfected with the GFP expression plasmid, persisting for a least 1 week.