Sentence examples for by sustained activation of from inspiring English sources

Ablation of NFATc2 and NFATc4 increases insulin sensitivity, in part, by sustained activation of the insulin signaling pathway.

However, in the injured brain this cross talk is presumably disturbed by sustained activation of microglia.

This difference was associated with persistent activation of NF-kappaB p65p50 heterodimers in the neonates in contrast to early, transient activation of p65p50 followed by sustained activation of p50p50 in the adults.

Although it has been established that progression of the disease is accompanied by sustained activation of microglia, the underlying molecules and factors involved in these immune-triggered mechanisms remain largely unexplored.

Nicotine enhances proliferation, accelerates tumor growth and inhibits apoptosis in certain types of human cancer cell lines and induces angiogenesis in vivo by sustained activation of the mitogenic pathways [9]-[11].

Recently it was shown that NK cell cytotoxicity is augmented by sustained activation of the MEK1/2 ERK pathway, but is significantly reduced by either pharmacologically blocking ERK activation (phosphorylation) or knockdown of ERK2 by RNAi [22].

Here we discuss that, at least in yeast, Sir2 activation prevents programmed cell death induced by the sustained activation of the stress activated protein kinase (SAPK) Hog1, the yeast homologue of the p38 SAPK.

In both cases, senescence was triggered by persistent DNA damages, accompanied by a sustained activation of CHK2 and release of chemokines, all characteristic of SASP.

This was accompanied not only by a sustained activation of NF-κB, but also by a significant increase in the expression of SUMO-1.

Our data are consistent with the inhibition of cell growth by a sustained activation of ERK1/2 (40), whereas the inhibition of SCC growth by inducing a sustained activation of EGFR has been also previously reported (50).

Recently, it has been shown that in H-Ras oncogene transformed fibroblasts, RhoA may cooperate in transformation by suppressing the cell cycle inhibitor p21WAF1 that is induced by the sustained activation of the ERK-MAP kinase pathway [ 3, 25].