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The relation between Pfmdr-1 86Y mutation in isolates from day of recurrence and clinical response to CQ treatment was assessed by survival analysis using the Kaplan-Meier method and the log-rank test.
Hazard rates were determined by survival analysis using the Cox proportional hazards model.
Efficacy rates were assessed by survival analysis using the Kaplan-Meier method.
Time to relapse will be assessed by survival analysis (using either proportional hazard or accelerated life-time models).
TTP, OS and the 95% confidence intervals were evaluated by survival analysis using Kaplan Meier method (Kaplan and Meier, 1985).
Time to progression, OS and the 95% confidence intervals for the groups with negative and positive biomarker were evaluated by survival analysis using Kaplan Meier method (Kaplan and Meier, 1985), and compared using the log-rank test.
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The relative influence of different variables on survival was studied by multivariate survival analysis using stepwise Cox regression.
The prognostic impact of clinical variables was tested by univariate survival analysis using the Kaplan Meier method and the log-rank test.
We therefore focused on the relationship between PRL-3 and survival in such patients with normal karyotype by Kaplan Meier survival analysis using the following three cohorts: (i) Cohort 1 (n = 101), (ii) GSE 6891 (n = 227) and (iii) GSE12417 (n = 163).
Survival estimates were assessed by a Kaplan-Meier analysis followed by a univariate Survival Analysis using a Wilcoxon test.
Significant differences between groups in all experiments were determined by Kaplan-Meier survival analysis using the biostatistics software GraphPad Prism 5. Curves were compared using the log-rank test.
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