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The wasp-induced JAK/STAT activity in muscles was significantly reduced by suppression of either gene (Fig 4J).
Invasive activities induced by PGE2 in MCF-7/DOX cells were inhibited by suppression of either EP1 or EP3 expression.
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Depending on the status of AR, suppression of either pathway by HOXB13 seems to inhibit the growth of prostate cancer cells.
Moreover, we also found that upon HDAC inhibition, another histone acetyltransferase EP300, and TYMS, a gene involved in nucleotide synthesis, are both transcriptionally downregulated upon HDAC inhibition (Supplementary Fig S5), and shRNA suppression of either gene by itself is lethal to cancer cells even without DNA damage (Supplementary Fig S6).
While MYC, P21, and AREG levels were confirmed to be affected by suppression of BRD4, we found that FAS was downregulated upon suppression of BRD2 only but not BRD4, while FGFR1 is upregulated upon suppression of either BRD3 or BRD4.
Remarkably, treatment of melanoma cells with TSH enhanced or synergized the expression of many of the iodide-handling genes induced either by suppression of one signaling pathway alone or simultaneous suppression of both pathways (Figure 2).
This is accomplished by suppression of ERK-mediated down-regulation of MyD88s.
This indicates that resveratrol inhibits cell growth by suppression of ftsZ expression.
Hashimoto, Y., Ookuma, S. & Nishida, E. Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans.
Directed therapy for patients with myelodysplastic syndromes (MDS) by suppression of cyclin D1 with ON 01910.Na.
Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis.
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